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Handbook of Chemical Biology of Nucleic Acids

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Cover of 'Handbook of Chemical Biology of Nucleic Acids'

Table of Contents

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    Book Overview
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    Chapter 1 High-Pressure Single-Molecule Studies on Non-canonical Nucleic Acids and Their Interactions
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    Chapter 2 Stability Prediction of Canonical and Noncanonical Structures of Nucleic Acids
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    Chapter 3 The Effect of Pressure on the Conformational Stability of DNA
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    Chapter 5 Quadruplexes Are Everywhere…On the Other Strand Too: The i-Motif
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    Chapter 8 NMR Study on Nucleic Acids
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    Chapter 9 Z-DNA
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    Chapter 10 Structures of G-Quadruplexes and Their Drug Interactions
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    Chapter 11 In Cell 19 F NMR for G-Quadruplex
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    Chapter 12 Structures and Catalytic Activities of Complexes Between Heme and DNA
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    Chapter 13 Studying Nucleic Acid-Ligand Binding by X-Ray Crystallography
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    Chapter 14 Predicting the 3D Structure of RNA from Sequence
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    Chapter 15 Hexitol Nucleic Acid (HNA): From Chemical Design to Functional Genetic Polymer
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    Chapter 16 The Effects of FANA Modifications on Non-canonical Nucleic Acid Structures
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    Chapter 17 Isomorphic Fluorescent Nucleoside Analogs
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    Chapter 18 Bridged Nucleic Acids for Therapeutic Oligonucleotides
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    Chapter 19 Mesyl Phosphoramidate Oligonucleotides: A New Promising Type of Antisense Agents
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    Chapter 20 Chemistry of Cyclic Dinucleotides and Analogs
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    Chapter 21 Labeling and Detection of Modified Nucleic Acids
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    Chapter 22 Cross-Linking Duplex of Nucleic Acids with Modified Oligonucleotides
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    Chapter 23 Enzymatic Synthesis of Base-Modified Nucleic Acids
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    Chapter 24 Charge Transfer in Natural and Artificial Nucleic Acids
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    Chapter 25 Nucleic Acid Aptamers: From Basic Research to Clinical Applications
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    Chapter 28 Targeting Quadruplex Nucleic Acids: The Bisquinolinium Saga
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    Chapter 29 Compound Shape and Substituent Effects in DNA Minor Groove Interactions
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    Chapter 30 Macrocyclic G-Quadruplex Ligands of Telomestatin Analogs
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    Chapter 31 Cyclic Naphthalene Diimide Derivatives as Novel DNA Ligands
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    Chapter 32 Imaging Study of Small Molecules to G-Quadruplexes in Cells
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    Chapter 34 DNA/Metal Cluster–Based Nano-lantern
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    Chapter 35 Interaction of Poly(Ethylene Glycol)-b-Poly-L-Lysine Copolymers with DNA Structures: A Thermodynamic Investigation
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    Chapter 36 Chemical Tools to Target Noncoding RNAs
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    Chapter 37 Targeting DNA Junctions with Small Molecules for Therapeutic Applications in Oncology
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    Chapter 38 DNA Damage and Repair in G-Quadruplexes Impact Gene Expression
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    Chapter 39 DNA Structural Elements as Potential Targets for Regulation of Gene Expression
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    Chapter 40 Effects of Molecular Crowding on Structures and Functions of Nucleic Acids
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    Chapter 41 Structure-Guided Optimization of siRNA and Anti-miRNA Properties
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    Chapter 42 Tools for Understanding the Chemical Biology of the tRNA Epitranscriptome
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    Chapter 43 Sulfur- and Selenium-Modified Bacterial tRNAs
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    Chapter 45 Chemical-Assisted Epigenome Sequencing
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    Chapter 47 Telomerase
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    Chapter 48 Genetic Alphabet Expansion of Nucleic Acids
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    Chapter 49 Unnatural Base Pairs to Expand the Genetic Alphabet and Code
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    Chapter 50 OGG1 at the Crossroads Between Repair and Transcriptional Regulation
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    Chapter 51 Phosphorothioate Nucleic Acids: Artificial Modification Envisaged by Nature
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    Chapter 52 Aptamer Molecular Evolution for Liquid Biopsy
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    Chapter 53 Single-Molecule DNA Visualization
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    Chapter 54 Tissue-Specific Drug Delivery Platforms Based on DNA Nanoparticles
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    Chapter 55 Nanobiodevice for Nucleic Acid Sensing
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    Chapter 56 Functional Nucleic Acid-Protein Complexes: Application to Fluorescent Ribonucleopeptide Sensors
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    Chapter 57 Detection Systems Using the Ternary Complex Formation of Nucleic Acids
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    Chapter 58 Nucleic Acid Conjugates for Biosensing: Design, Preparation, and Application
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    Chapter 59 Molecular Beacons With and Without Quenchers
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    Chapter 60 Gene Nanovector for Genome Therapy
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    Chapter 61 The Frame-Guided Assembly of Nucleic Acids
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    Chapter 62 Graphene Oxide and Nucleic Acids
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    Chapter 63 Carbon Nanotubes and Nucleic Acids
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    Chapter 64 Artificial Genetic Switches and DNA Origami: Current Landscape and Prospects as Designer Therapeutics and Visualization Tools
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    Chapter 65 Functional Engineering of Synthetic RNA Through Circularization
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    Chapter 66 Stimuli-Responsive DNA Nanostructures for Biomedical Applications
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    Chapter 67 Flex-Nucleosides: A Strategic Approach to Antiviral Therapeutics
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    Chapter 68 Small Molecules Targeting Repeat Sequences Causing Neurological Disorders
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    Chapter 69 Targeted Cancer Therapy: KRAS-Specific Treatments for Pancreatic Cancer
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    Chapter 70 Functional XNA and Biomedical Application
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    Chapter 71 Controlled Intracellular Trafficking and Gene Silencing by Oligonucleotide-Signal Peptide Conjugates
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    Chapter 72 First- and Second-Generation Nucleoside Triphosphate Prodrugs: Tri PPP ro-Compounds for Antiviral Chemotherapy
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    Chapter 73 New Molecular Technologies for Oligonucleotide Therapeutics-1: Properties and Synthesis of Boranophosphate DNAs
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    Chapter 74 Extracellular Vesicle-Mediated CRISPR/Cas Delivery: Their Applications in Molecular Imaging and Precision Biomedicine
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    Chapter 75 Advancing XNAzymes as Nucleic Acid Therapeutics
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    Chapter 76 Amides and Other Nonionic Backbone Modifications in RNA
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    Chapter 77 Expanding the RNA- and RNP-Based Regulatory World in Mammalian Cells
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    Chapter 78 Design and Biological Application of RTK Agonist Aptamers
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    Chapter 79 G-Quadruplex-Based Aptamers in Therapeutic Applications
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    Chapter 80 Nucleic Acids in Green Chemistry
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    Chapter 81 G-Quadruplexes in Human Viruses: A Promising Route to Innovative Antiviral Therapies
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    Chapter 84 Nonchromatographic Purification of Synthetic RNA
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    Chapter 85 Genome Editing Using CRISPR
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    Chapter 86 Biomaterials Based on DNA Conjugates and Assemblies
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    Chapter 88 Targeting DNA with Triplexes
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    Chapter 89 Metal Ion-Induced Changes in the Stability of DNA Duplexes
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    Chapter 90 Liquid-Liquid Phase Separation and Nucleic Acids
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    Chapter 91 Natural Riboswitches
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    Chapter 93 External Stimulation-Responsive Artificial Nucleic Acids: Peptide Ribonucleic Acid (PRNA)-Programmed Assemblies
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    Chapter 96 Targeting RNA with Small Molecules
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    Chapter 97 i-Motif Nucleic Acids
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    Chapter 98 Gene-Like Precise Construction of Functional DNA Materials
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    Chapter 99 Design and Self-Assembly of Therapeutic Nucleic Acid Nanoparticles (NANPs) with Controlled Immunological Properties
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    Chapter 100 Nanomaterials for Therapeutic Nucleic Acid Delivery
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    Chapter 101 G-Quadruplex Resolving by Specific Helicases
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    Chapter 102 Binding and Modulation of G-Quadruplex DNA and RNA Structures by Proteins
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    Chapter 103 New Molecular Technologies for Oligonucleotide Therapeutics-2: A-Type Nucleic Acid Duplex-Specific Binding Oligocationic Molecules for Oligonucleotide Therapeutics
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    Chapter 104 Telomeres: Structure and Function
Attention for Chapter 13: Studying Nucleic Acid-Ligand Binding by X-Ray Crystallography
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Chapter title
Studying Nucleic Acid-Ligand Binding by X-Ray Crystallography
Chapter number 13
Book title
Handbook of Chemical Biology of Nucleic Acids
Published by
Springer, Singapore, January 2023
DOI 10.1007/978-981-19-9776-1_13
Book ISBNs
978-9-81-199775-4, 978-9-81-199776-1
Authors

Cardin, Christine J., McQuaid, Kane T.

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