Chapter title |
Galleria Mellonella as a Model Host to Study Gut Microbe Homeostasis and Brain Infection by the Human Pathogen Listeria Monocytogenes.
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Chapter number | 203 |
Book title |
Yellow Biotechnology I
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Published in |
Advances in biochemical engineering biotechnology, May 2013
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DOI | 10.1007/10_2013_203 |
Pubmed ID | |
Book ISBNs |
978-3-64-239862-9, 978-3-64-239863-6
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Authors |
Mukherjee K, Raju R, Fischer R, Vilcinskas A, Krishnendu Mukherjee, Ramya Raju, Rainer Fischer, Andreas Vilcinskas, Mukherjee, Krishnendu, Raju, Ramya, Fischer, Rainer, Vilcinskas, Andreas |
Abstract |
The gastrointestinal tract in both mammals and insects is associated with microbes (collectively the microbiota), which are controlled by the intestinal immune system. These microbes regulate pathogens that can infect gut epithelial cells, and there is increasing evidence for a reciprocal relationship between beneficial and pathogenic bacteria in the gut and the intestinal immune system. Deciphering these complex interactions between the microbiota and intestinal immune system in mammals requires surrogate model systems, such as larvae of the greater wax moth Galleria mellonella. The exposure of G. mellonella microbiota to antibiotics induces immunity and stress-related genes in the intestine. The model can also provide insight into the virulence mechanisms of pathogens such as Listeria monocytogenes in the human gut and brain. We also discuss the current uses of G. mellonella as a model to develop therapeutic strategies against listeriosis. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Unknown | 41 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 19% |
Student > Master | 8 | 19% |
Student > Bachelor | 5 | 12% |
Researcher | 5 | 12% |
Student > Postgraduate | 3 | 7% |
Other | 5 | 12% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 16 | 38% |
Biochemistry, Genetics and Molecular Biology | 8 | 19% |
Immunology and Microbiology | 4 | 10% |
Nursing and Health Professions | 1 | 2% |
Environmental Science | 1 | 2% |
Other | 2 | 5% |
Unknown | 10 | 24% |