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Kidney Research

Overview of attention for book
Cover of 'Kidney Research'

Table of Contents

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    Chapter 9 Standardized Protocol for the Preparation of Precision-Cut Kidney Slices: A Translational Model of Renal Fibrosis
Attention for Chapter: Generating Human Glomeruli from Pluripotent Stem Cells for Disease Modelling and Drug Screening.
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  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

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Chapter title
Generating Human Glomeruli from Pluripotent Stem Cells for Disease Modelling and Drug Screening.
Book title
Kidney Research
Published in
Methods in molecular biology, January 2023
DOI 10.1007/978-1-0716-3179-9_5
Pubmed ID
37423982
Book ISBNs
978-1-07-163178-2, 978-1-07-163179-9
Authors

Hale, Lorna J, Little, Melissa H, Hale, Lorna J., Little, Melissa H.

Abstract

The functional unit of human kidney is the nephron. This structure is composed of a glomerulus, connected to a tubule that drains into a collecting duct. The cells which make up the glomerulus are critically important to the appropriate function of this specialised structure. Damage to glomerular cells, particularly the podocytes, is the primary cause of numerous kidney diseases. However, access to and the subsequent culture of human glomerular cells is limited. As such, the ability to generate human glomerular cell types from induced pluripotent stem cells (iPSCs) at scale has garnered great interest. Here, we describe a method to isolate, culture and study 3D human glomeruli from induced pluripotent stem cell (iPSC)-derived kidney organoids in vitro. These 3D glomeruli retain appropriate transcriptional profiles and can be generated from any individual. As isolated glomeruli, they have applicability for disease modelling and drug discovery.

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 Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2023.
All research outputs
#14,623,337
of 25,123,616 outputs
Outputs from Methods in molecular biology
#3,848
of 14,116 outputs
Outputs of similar age
#186,788
of 473,696 outputs
Outputs of similar age from Methods in molecular biology
#108
of 720 outputs
Altmetric has tracked 25,123,616 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,116 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 473,696 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 720 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.

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