Chapter title |
Hepatitis E Virus Life Cycle.
|
---|---|
Book title |
Hepatitis E Virus
|
Published in |
Advances in experimental medicine and biology, May 2023
|
DOI | 10.1007/978-981-99-1304-6_10 |
Pubmed ID | |
Book ISBNs |
978-9-81-991303-9, 978-9-81-991304-6
|
Authors |
Ju, Xiaohui, Dong, Lin, Ding, Qiang, Xiaohui Ju, Lin Dong, Qiang Ding |
Abstract |
Hepatitis E virus (HEV) infects over 20 million people worldwide per year, leading to 30,000-40,000 deaths. In most cases HEV infection in a self-limited, acute illness. However, chronic infections could occur in immunocompromised individuals. Due to scarcity of robust cell culture models in vitro and genetic tractable animal models in vivo, the details of HEV life cycle, as well as its interaction with host cells still remain elusive, which dampens antivirals discovery. In this chapter, we present an update in the HEV infectious cycle steps: entry, genome replication/subgenomic RNA transcription, assembly, and release. Moreover, we discussed the future prospective on HEV research and illustrates important questions urgently to be addressed. |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 1 | 50% |
Student > Master | 1 | 50% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 1 | 50% |
Immunology and Microbiology | 1 | 50% |