Non-Ribosomal Peptide Biosynthesis and Engineering
Springer US
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| Chapter title |
Structural Studies of Modular Nonribosomal Peptide Synthetases.
|
|---|---|
| Book title |
Non-Ribosomal Peptide Biosynthesis and Engineering
|
| Published in |
Methods in molecular biology, January 2023
|
| DOI | 10.1007/978-1-0716-3214-7_2 |
| Pubmed ID | |
| Book ISBNs |
978-1-07-163213-0, 978-1-07-163214-7
|
| Authors |
Patel, Ketan D, Ahmed, Syed Fardin, MacDonald, Monica R, Gulick, Andrew M, Patel, Ketan D., MacDonald, Monica R., Gulick, Andrew M. |
| Abstract |
The non-ribosomal peptide synthetases (NRPSs) are a family of modular enzymes involved in the production of peptide natural products. Not restricted by the constraints of ribosomal peptide and protein production, the NRPSs are able to incorporate unusual amino acids and other suitable building blocks into the final product. The NRPSs operate with an assembly line strategy in which peptide intermediates are covalently tethered to a peptidyl carrier protein and transported to different catalytic domains for the multiple steps in the biosynthesis. Often the carrier and catalytic domains are joined into a single large multidomain protein. This chapter serves to introduce the NRPS enzymes, using the nocardicin NRPS system as an example that highlights many common features to NRPS biochemistry. We then describe recent advances in the structural biology of NRPSs focusing on large multidomain structures that have been determined. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 1 | 33% |
| Lecturer | 1 | 33% |
| Researcher | 1 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 1 | 33% |
| Biochemistry, Genetics and Molecular Biology | 1 | 33% |
| Agricultural and Biological Sciences | 1 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2023.
All research outputs
#16,492,007
of 24,267,449 outputs
Outputs from Methods in molecular biology
#5,714
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Outputs of similar age
#250,023
of 446,503 outputs
Outputs of similar age from Methods in molecular biology
#263
of 669 outputs
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