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The Immune Synapse

Overview of attention for book
Cover of 'The Immune Synapse'

Table of Contents

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    Book Overview
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    Chapter 11 Separation of Single Core and Multicore Lytic Granules by Subcellular Fractionation and Immunoisolation
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    Chapter 17 Bottom-Up Assembly of Bioinspired, Fully Synthetic Extracellular Vesicles
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    Chapter 22 Functionalized Lipid Droplets and Microfluidics Approach to Study Immune Cell Polarity In Vitro
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    Chapter 25 Isolation of the B Cell Immune Synapse for Proteomic Analysis
Attention for Chapter: Combined FRET-FLIM and NAD(P)H FLIM to Analyze B Cell Receptor Signaling Induced Metabolic Activity of Germinal Center B Cells In Vivo.
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

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Citations

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Chapter title
Combined FRET-FLIM and NAD(P)H FLIM to Analyze B Cell Receptor Signaling Induced Metabolic Activity of Germinal Center B Cells In Vivo.
Book title
Methods in Molecular Biology
Published in
Methods in molecular biology, January 2023
DOI 10.1007/978-1-0716-3135-5_6
Pubmed ID
37106177
Book ISBNs
978-1-07-163134-8, 978-1-07-163135-5
Authors

Ulbricht, Carolin, Leben, Ruth, Cao, Yu, Niesner, Raluca A, Hauser, Anja E, Niesner, Raluca A., Hauser, Anja E.

Abstract

Affinity maturation of B cell clones within germinal centers constitutes an important mechanism for immune memory. During this process, B cell receptor signaling capacity is tested in multiple rounds of positive selection. Antigen stimulation and co-stimulatory signals mobilize calcium to switch on gene expression leading to proliferation and survival and to differentiation into memory B cells and plasma cells. Additionally, all these processes require adaption of B cell metabolism, and calcium signaling and metabolic pathways are closely interlinked. Mitochondrial adaption, ROS production, and NADPH oxidase activation are involved in cell fate decisions, but it remains elusive to what extent, especially because the analysis of these dynamic processes in germinal centers has to take place in vivo. Here, we introduce a quantitative intravital imaging method for combined measurement of cytoplasmic calcium concentration and enzymatic fingerprinting in germinal center B cells as a possible tool in order to further examine the relationship of calcium signaling and immunometabolism.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 50%
Student > Doctoral Student 1 50%
Readers by discipline Count As %
Physics and Astronomy 1 50%
Engineering 1 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2023.
All research outputs
#14,714,319
of 24,679,965 outputs
Outputs from Methods in molecular biology
#3,958
of 13,874 outputs
Outputs of similar age
#193,040
of 461,599 outputs
Outputs of similar age from Methods in molecular biology
#119
of 718 outputs
Altmetric has tracked 24,679,965 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,874 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 461,599 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 718 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.

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