Chapter title |
Bioconversion of Methanol by Synthetic Methylotrophy.
|
---|---|
Chapter number | 176 |
Book title |
One-Carbon Feedstocks for Sustainable Bioproduction
|
Published in |
Advances in biochemical engineering biotechnology, September 2021
|
DOI | 10.1007/10_2021_176 |
Pubmed ID | |
Book ISBNs |
978-3-03-106853-9, 978-3-03-106854-6
|
Authors |
Guo, Feng, Zhang, Shangjie, Jiang, Yujia, Xu, Huixin, Xin, Fengxue, Zhang, Wenming, Jiang, Min, Feng Guo, Shangjie Zhang, Yujia Jiang, Huixin Xu, Fengxue Xin, Wenming Zhang, Min Jiang |
Abstract |
As an important building block in the chemical industry, methanol has become an attractive substrate in biorefinery owing to its abundance and low cost. With the development of synthetic biology, metabolic engineering of non-methylotrophy to construct synthetic methylotrophy has drawn increased attention. As for the metabolic construction of methanol assimilation pathway in some industrial hosts, several artificial methanol assimilation pathways have recently been designed and constructed based on the computer-aided design. Particularly, these artificial methanol assimilation pathways possess advantages of shorter reaction steps, stronger driving forces, and independence on oxygen. Accordingly, this chapter reviewed strategies of constructing synthetic methylotrophs, including introducing methanol metabolic modules derived from natural methylotrophs and designing artificial methanol assimilation pathways. Future challenges and prospects were also discussed. |
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Mendeley readers
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