Chapter title |
Pseudotyped Virus for Flaviviridae.
|
---|---|
Chapter number | 17 |
Book title |
Pseudotyped Viruses
|
Published in |
Advances in experimental medicine and biology, January 2023
|
DOI | 10.1007/978-981-99-0113-5_17 |
Pubmed ID | |
Book ISBNs |
978-9-81-990112-8, 978-9-81-990113-5
|
Authors |
Zhang, Leiliang, Wang, Xiao, Ming, Annan, Tan, Wenjie |
Abstract |
Members of Flaviviridae are enveloped single positive-stranded RNA viruses including hepacivirus, pestivirus, pegivirus, and mosquito-transmitted flavivirus, which are important pathogens of infectious diseases and pose serious threats to human health. Pseudotyped virus is an artificially constructed virus-like particle, which could infect host cells similar to a live virus but cannot produce infectious progeny virus. Therefore, pseudotyped virus has the advantages of a wide host range, high transfection efficiency, low biosafety risk, and accurate and objective quantification. It has been widely used in biological characteristics, drug screening, detection methods, and vaccine evaluation of Flaviviridae viruses like hepatitis C virus, Japanese encephalitis virus, dengue virus, and Zika virus. |
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