Report for: Pharmacogenomics in Drug Discovery and Development

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Chapter title	Pharmacogenetics of membrane transporters: a review of current approaches.
Chapter number	4
Book title	Pharmacogenomics in Drug Discovery and Development
Published in	Methods in molecular biology, March 2008
DOI	10.1007/978-1-59745-205-2_4
Pubmed ID	18370230
Book ISBNs	978-1-58829-887-4, 978-1-59745-205-2
Authors	Sissung TM, Gardner ER, Gao R, Figg WD, Tristan M. Sissung, Erin R. Gardner, Rui Gao, William D. Figg, Sissung, Tristan M., Gardner, Erin R., Gao, Rui, Figg, William D.
Abstract	This chapter provides a review of the pharmacogenetics of membrane transporters, including adenosine triphosphate-binding cassette (ABC) transporters and organic anion transporting proteins (OATPs). Membrane transporters are heavily involved in drug disposition by actively transporting substrate drugs between organs and tissues. As such, polymorphisms in the genes encoding these proteins may have a significant effect on the absorption, distribution, metabolism, and excretion of compounds. The techniques used to identify substrates and inhibitors of these proteins and subsequently assess the effect of genetic mutation on transport, both in vitro and in vivo, are outlined and discussed. Finally, studies linking transporter genotype with clinical outcomes are discussed.

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United States	2	10%
Unknown	18	90%

Demographic breakdown

Readers by professional status	Count	As %
Researcher	6	30%
Student > Ph. D. Student	5	25%
Student > Postgraduate	2	10%
Student > Master	2	10%
Other	1	5%
Other	1	5%
Unknown	3	15%

Readers by discipline	Count	As %
Medicine and Dentistry	8	40%
Agricultural and Biological Sciences	4	20%
Pharmacology, Toxicology and Pharmaceutical Science	2	10%
Immunology and Microbiology	1	5%
Chemical Engineering	1	5%
Other	0	0%
Unknown	4	20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2011.

All research outputs

#20,191,579

of 22,708,120 outputs

Outputs from Methods in molecular biology

#9,849

of 13,077 outputs

Outputs of similar age

#78,901

of 82,077 outputs

Outputs of similar age from Methods in molecular biology

#18

of 25 outputs

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So far Altmetric has tracked 13,077 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.

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Pharmacogenomics in Drug Discovery and Development

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Attention Score in Context