Chapter title |
Migraine models.
|
---|---|
Chapter number | 9 |
Book title |
Analgesia
|
Published in |
Methods in molecular biology, December 2009
|
DOI | 10.1007/978-1-60327-323-7_9 |
Pubmed ID | |
Book ISBNs |
978-1-60327-322-0, 978-1-60327-323-7
|
Authors |
Benemei S, De Cesaris F, Nicoletti P, Materazzi S, Nassini R, Geppetti P, Silvia Benemei, Francesco De Cesaris, Paola Nicoletti, Serena Materazzi, Romina Nassini, Pierangelo Geppetti, Benemei, Silvia, De Cesaris, Francesco, Nicoletti, Paola, Materazzi, Serena, Nassini, Romina, Geppetti, Pierangelo |
Abstract |
Migraine is a high prevalence disorder which affects a significant proportion of the general population, especially women during their central and more productive time of the life, thus causing severe disability. The genetic basis of the disease is unknown and the mechanism is poorly understood. The possibility that following a perturbation in the central nervous system, and particularly in the brainstem, trigeminal neurons become hyperexcitable and produce an uncontrolled release of sensory neuropeptides which eventually results in arterial vasodilatation and neuronal sensitization, has been gaining credit from studies in experimental animals and humans. In particular, experimental and clinical data with antagonists of the calcitonin gene-related peptide (CGRP) propose this molecule and its receptor as a major target for migraine treatment. |
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