Report for: Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1

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Chapter title	The Role of Epigenetics in Brain and Spinal Cord Tumors.
Chapter number	8
Book title	Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1
Published in	Advances in experimental medicine and biology, January 2023
DOI	10.1007/978-3-031-14732-6_8
Pubmed ID	36587385
Book ISBNs	978-3-03-114731-9, 978-3-03-114732-6
Authors	Park, Sung-Hye, Sung-Hye Park
Abstract	Identification of distinct genetic and epigenetic profiles in various neuroepithelial tumors has improved the classification and uncovered novel diagnostic, prognostic, and predictive molecular biomarkers for improved prediction of treatment response and outcome. Especially, in pediatric high-grade brain tumors, such as diffuse midline glioma, H3K27M-altered and posterior fossa group A-ependymoma, epigenetic changes predominate, along with changes in expression of known oncogenes and tumor suppressor genes induced by histone modifications and DNA methylation. The precise role of epigenetic abnormalities is important for understanding tumorigenesis and the establishment of brain tumor treatment strategies. Using powerful epigenetic-based therapies for cancer cells, the aberrantly regulated epigenome can be restored to a more normal state through epigenetic reprogramming. Combinations of agents targeting DNA methylation and/or other epigenetic modifications may be a promising cancer treatment. Therefore, the integration of multi-omics data including epigenomics is now important for classifying primary brain tumors and predicting their biological behavior. Recent advances in molecular genetics and epigenetic integrated diagnostics of brain tumors influence new strategies for targeted therapy.

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Country	Count	As %
Unknown	2	100%

Demographic breakdown

Type	Count	As %
Members of the public	2	100%

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The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

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Country	Count	As %
Unknown	4	100%

Demographic breakdown

Readers by professional status	Count	As %
Professor	1	25%
Researcher	1	25%
Student > Master	1	25%
Unknown	1	25%

Readers by discipline	Count	As %
Medicine and Dentistry	2	50%
Biochemistry, Genetics and Molecular Biology	1	25%
Unknown	1	25%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2023.

All research outputs

#15,276,227

of 23,476,369 outputs

Outputs from Advances in experimental medicine and biology

#2,332

of 5,037 outputs

Outputs of similar age

#212,787

of 432,336 outputs

Outputs of similar age from Advances in experimental medicine and biology

#25

of 98 outputs

Altmetric has tracked 23,476,369 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.

So far Altmetric has tracked 5,037 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 432,336 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.

We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.

Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1

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