Chapter title |
Role of central/peripheral chemoreceptors and their interdependence in the pathophysiology of sleep apnea.
|
---|---|
Chapter number | 46 |
Book title |
Arterial Chemoreception
|
Published in |
Advances in experimental medicine and biology, January 2012
|
DOI | 10.1007/978-94-007-4584-1_46 |
Pubmed ID | |
Book ISBNs |
978-9-40-074583-4, 978-9-40-074584-1
|
Authors |
Dempsey, Jerome A, Smith, Curtis A, Blain, Gregory M, Xie, Ailiang, Gong, Yuansheng, Teodorescu, Mihaela, Jerome A. Dempsey, Curtis A. Smith, Gregory M. Blain, Ailiang Xie, Yuansheng Gong, Mihaela Teodorescu, Dempsey, Jerome A., Smith, Curtis A., Blain, Gregory M. |
Abstract |
Unstable periodic breathing with intermittent ventilatory overshoots and undershoots commonly occurs in chronic heart failure, in hypoxia, with chronic opioid use and in certain types of obstructive sleep apnea. Sleep promotes breathing instability because it unmasks a highly sensitive dependence of the respiratory control system on chemoreceptor input, because transient cortical arousals promote ventilatory overshoots and also because upper airway dilator muscle tonicity is reduced and airway collapsibility enhanced. We will present data in support of the premise that carotid chemoreceptors are essential in the pathogenesis of apnea and periodicity; however it is the hyperadditive influence of peripheral chemoreceptor sensory input on central chemosensitivity that accounts for apnea and periodic breathing. This chemoreceptor interdependence also provides a significant portion of the normal drive to breathe in normoxia (i.e. eupnea) and in acute hypoxia. Finally, we discuss the effects of preventing transient hypocapnia (via selective increases in FICO(2)) on centrally mediated types of periodic breathing and even some varieties of cyclical obstructive sleep apnea. |
X Demographics
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Egypt | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 19% |
Student > Doctoral Student | 6 | 13% |
Other | 5 | 11% |
Student > Ph. D. Student | 5 | 11% |
Lecturer | 3 | 6% |
Other | 11 | 23% |
Unknown | 8 | 17% |
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Neuroscience | 5 | 11% |
Sports and Recreations | 4 | 9% |
Agricultural and Biological Sciences | 4 | 9% |
Engineering | 3 | 6% |
Other | 0 | 0% |
Unknown | 12 | 26% |