Chapter title |
Motor and Speech Disorders in Classic Galactosemia.
|
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Chapter number | 219 |
Book title |
JIMD Reports - Volume 11
|
Published in |
JIMD Reports, April 2013
|
DOI | 10.1007/8904_2013_219 |
Pubmed ID | |
Book ISBNs |
978-3-64-237327-5, 978-3-64-237328-2
|
Authors |
Nancy L. Potter, Yves Nievergelt, Lawrence D. Shriberg, Potter, Nancy L., Nievergelt, Yves, Shriberg, Lawrence D. |
Editors |
Johannes Zschocke, K Michael Gibson, Garry Brown, Eva Morava, Verena Peters |
Abstract |
Purpose To test the hypothesis that children with classic galactosemia and speech disorders are at risk for co-occurring strength and coordination disorders. Method This is a case-control study of 32 children (66% male) with galactosemia and neurologic speech disorders and 130 controls (50% male) ages 4-16 years. Speech was assessed using the Percentage of Consonants Correct (PCC) metric from responses to the Goldman-Fristoe Test of Articulation-2 and from a 5-min recorded speech sample, hand and tongue strength using the Iowa Oral Performance Instrument, and coordination using the Movement Assessment Battery for Children. The number of days on milk during the neonatal period was obtained by parent report. Analyses of covariance, distributions, and correlations were used to evaluate relationships among speech, strength, coordination, age, gender, and days on milk. Results Children with galactosemia had weaker hand and tongue strength and most (66%) had significant coordination disorders, primarily affecting balance and manual dexterity. Among children with galactosemia, children with more speech errors and classified as childhood apraxia of speech (n = 7) and ataxic dysarthria (n = 1), had poorer balance and manual dexterity, but not weaker hand or tongue strength, compared to the children with fewer speech errors. The number of days on milk during the neonatal period was associated with more speech errors in males but not in females. Conclusion Children with galactosemia have a high prevalence of co-occurring speech, coordination, and strength disorders, which may be evidence of a common underlying etiology, likely associated with diffuse cerebellar damage, rather than distinct disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 14% |
United States | 1 | 14% |
Canada | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 57% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Scientists | 1 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 2% |
Unknown | 47 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 17% |
Student > Bachelor | 6 | 13% |
Student > Ph. D. Student | 6 | 13% |
Student > Doctoral Student | 3 | 6% |
Researcher | 3 | 6% |
Other | 7 | 15% |
Unknown | 15 | 31% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 23% |
Nursing and Health Professions | 6 | 13% |
Agricultural and Biological Sciences | 4 | 8% |
Psychology | 4 | 8% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Other | 3 | 6% |
Unknown | 17 | 35% |