Chapter title |
Calcium binding proteins.
|
---|---|
Chapter number | 19 |
Book title |
Calcium Signaling
|
Published in |
Advances in experimental medicine and biology, January 2012
|
DOI | 10.1007/978-94-007-2888-2_19 |
Pubmed ID | |
Book ISBNs |
978-9-40-072887-5, 978-9-40-072888-2
|
Authors |
Matilde Yáñez, José Gil-Longo, Manuel Campos-Toimil, Matilde Yáñez, José Gil-Longo, Yáñez, Matilde, Gil-Longo, José, Campos-Toimil, Manuel |
Abstract |
The role of Ca(2+) as a key and pivotal second messenger in cells depends largely on a wide number of heterogeneous so-called calcium binding proteins (CBP), which have the ability to bind this ion in specific domains. CBP contribute to the control of Ca(2+) concentration in the cytosol and participate in numerous cellular functions by acting as Ca(2+) transporters across cell membranes or as Ca(2+)-modulated sensors, i.e., decoding Ca(2+) signals. In this chapter we review the main Ca(2+)-modulated CBP, starting with those intracellular CBP that contain the structural EF-hand domain: parvalbumin, calmodulin, S100 proteins and calcineurin. Then, we address intracellular CBP lacking the EF-hand domain: CBP within intracellular Ca(2+) stores (paying special attention to calreticulin and calsequestrin), annexins and proteins that contain a C2 domain, such as protein kinase C (PKC) or sinaptotagmin. Finally, extracellular CBP have been classified in six groups, according to their Ca(2+) binding structures: (i) EF-hand domains; (ii) EGF-like domains; (iii) γ-carboxyl glutamic acid (GLA)-rich domains; (iv) cadherin domains; (v) Ca(2+)-dependent (C)-type lectin-like domains; (vi) Ca(2+)-binding pockets of family C G-protein-coupled receptors. For all proteins, we briefly review their structure, location and function and additionally their potential as pharmacological targets in several human diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 2 | <1% |
United Kingdom | 2 | <1% |
United States | 2 | <1% |
India | 2 | <1% |
Mexico | 2 | <1% |
Hungary | 1 | <1% |
Austria | 1 | <1% |
Unknown | 250 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 76 | 29% |
Researcher | 36 | 14% |
Student > Master | 34 | 13% |
Student > Bachelor | 22 | 8% |
Student > Postgraduate | 12 | 5% |
Other | 42 | 16% |
Unknown | 40 | 15% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 94 | 36% |
Biochemistry, Genetics and Molecular Biology | 48 | 18% |
Chemistry | 17 | 6% |
Neuroscience | 13 | 5% |
Medicine and Dentistry | 11 | 4% |
Other | 31 | 12% |
Unknown | 48 | 18% |