Chapter title |
Array-CGH Analysis of Cutaneous Anaplastic Large Cell Lymphoma
|
---|---|
Chapter number | 13 |
Book title |
Array Comparative Genomic Hybridization
|
Published in |
Methods in molecular biology, January 2013
|
DOI | 10.1007/978-1-62703-281-0_13 |
Pubmed ID | |
Book ISBNs |
978-1-62703-280-3, 978-1-62703-281-0
|
Authors |
K. Szuhai, R. van Doorn, C. P. Tensen, Van Kester, Szuhai, K., Doorn, R. van, Tensen, C. P., Kester, Van |
Abstract |
This chapter describes a study in which the pattern of numerical chromosomal alterations in cutaneous anaplastic large cell lymphoma (C-ALCL) tumor samples was defined using array-based comparative genomic hybridization (CGH). First, the array-based CGH technique applied is outlined in detail. Next, its application in the analysis of C-ALCL tumor specimens is described. This approach resulted in the identification of highly recurrent chromosomal alterations in C-ALCL that include gain of 7q31 and loss on 6q16-6q21 and 13q34, each affecting 45% of the patients. The pattern characteristic of C-ALCL differs markedly from chromosomal alterations observed in other CTCL such as mycosis fungoides and Sézary syndrome and yielded several candidate genes with potential relevance in the pathogenesis of C-ALCL. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 3 | 43% |
Researcher | 3 | 43% |
Student > Master | 1 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 43% |
Biochemistry, Genetics and Molecular Biology | 2 | 29% |
Agricultural and Biological Sciences | 1 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 14% |