Chapter title |
Targeted Locus Amplification as Marker Screening Approach to Detect Immunoglobulin (IG) Translocations in B-Cell Non-Hodgkin Lymphomas
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Book title |
Immunogenetics
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Published in |
Methods in molecular biology, January 2022
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DOI | 10.1007/978-1-0716-2115-8_8 |
Pubmed ID | |
Book ISBNs |
978-1-07-162114-1, 978-1-07-162115-8
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Authors |
Genuardi, Elisa, Alessandria, Beatrice, Civita, Aurora Maria, Ferrero, Simone, Elisa Genuardi, Beatrice Alessandria, Aurora Maria Civita, Simone Ferrero |
Abstract |
Although MRD monitoring by the classic polymerase chain reaction (PCR) approach is a powerful outcome predictor, about 20% of mantle cell lymphoma (MCL) and 50% of follicular lymphoma (FL) patients still lack a molecular marker and are thus resulting not eligible for MRD monitoring. Targeted locus amplification (TLA), a new NGS technology, has been revealed as a feasible marker screening approach able to identify uncommon B-cell leukemia/lymphoma 1 (BCL1) and B-cell leukemia/lymphoma 2 (BCL2) rearrangements in MCL and FL cases defined as having "no marker" by the classic PCR approach. |
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