| Chapter title |
Translational Neuropsychopharmacology
|
|---|---|
| Chapter number | 5001 |
| Book title |
Translational Neuropsychopharmacology
|
| Published in |
Current topics in behavioral neurosciences, September 2016
|
| DOI | 10.1007/7854_2015_5001 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-933911-5, 978-3-31-933913-9
|
| Authors |
Barnett, Jennifer H, Blackwell, Andrew D, Sahakian, Barbara J, Robbins, Trevor W, Jennifer H. Barnett, Andrew D. Blackwell, Barbara J. Sahakian, Trevor W. Robbins, Barnett, Jennifer H., Blackwell, Andrew D., Sahakian, Barbara J., Robbins, Trevor W. |
| Editors |
Trevor W. Robbins, Barbara J. Sahakian |
| Abstract |
The origins and rationale of the Cambridge Neuropsychological Test Automated Battery (CANTAB) as a cross-species translational instrument suitable for use in human neuropsychopharmacological studies are reviewed. We focus on its use for the early assessment and detection of Alzheimer's disease, in particular the Paired Associates Learning (PAL) test. We consider its psychometric properties, neural validation, and utility, including studies on large samples of healthy volunteers, patients with mild cognitive impairment (MCI), and Alzheimer's disease. We demonstrate how it can be applied in cross-species studies using experimental animals to bridge the cross-species translational 'gap'. We also show how the CANTAB PAL has bridged a second translational 'gap' through its application to the early detection of memory problems in primary care clinics, using iPad technology. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 163 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 17% |
| Student > Ph. D. Student | 25 | 15% |
| Student > Bachelor | 14 | 9% |
| Other | 13 | 8% |
| Student > Master | 12 | 7% |
| Other | 23 | 14% |
| Unknown | 48 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 32 | 20% |
| Medicine and Dentistry | 25 | 15% |
| Neuroscience | 20 | 12% |
| Agricultural and Biological Sciences | 6 | 4% |
| Social Sciences | 5 | 3% |
| Other | 19 | 12% |
| Unknown | 56 | 34% |