Chapter title |
Array CGH Reveals Clonal Evolution of Adult T-Cell Leukemia/Lymphoma.
|
---|---|
Chapter number | 12 |
Book title |
Array Comparative Genomic Hybridization
|
Published in |
Methods in molecular biology, January 2013
|
DOI | 10.1007/978-1-62703-281-0_12 |
Pubmed ID | |
Book ISBNs |
978-1-62703-280-3, 978-1-62703-281-0
|
Authors |
Akira Umino, Masao Seto, Umino, Akira, Seto, Masao |
Abstract |
Adult T-cell leukemia/lymphoma (ATLL) is the neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). We performed oligoarray comparative genomic hybridization (CGH) against paired samples comprising peripheral blood (PB) and lymph node (LN) samples from patients with acute-type ATLL. Results disproved the established theory that true monoclonal proliferation, such as identical clonal expansion in all respects, occurred in acute-type ATLL, and our findings revealed that acute-type ATLL contains multiple subclones with differing genomic aberrations. Oligoarray CGH technology has been developed not only for high-resolution application but also for use in various analyses. Our original analysis is a method of identifying two or more clones with different chromosomal aberrations in one sample. Herein, we describe the analysis and clonal evolution of acute-type ATLL. |
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