Stephen D Hursting, Hursting SD, Stephen D. Hursting, Hursting, Stephen D.
Editors
Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione
Abstract
Nearly 36 % of adults and 20 % of children in the USA are obese, defined as a body mass index (BMI) ≥30 kg/m(2). Obesity, which is accompanied by metabolic dysregulation often manifesting in the metabolic syndrome, is an established risk factor for many cancers. Within the growth-promoting, proinflammatory environment of the obese state, cross talk between macrophages, adipocytes, and epithelial cells occurs via obesity-associated hormones, cytokines, and other mediators that may enhance cancer risk and/or progression. This chapter synthesizes the evidence on key biological mechanisms underlying the obesity-cancer link, with particular emphasis on obesity-associated enhancements in growth factor signaling, inflammation, and vascular integrity processes, as well as obesity-dependent microenvironmental perturbations, including the epithelial-to-mesenchymal transition. These interrelated pathways represent possible mechanistic targets for disrupting the obesity-cancer link.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2014.
All research outputs
#17,699,064
of 22,725,280 outputs
Outputs from Cancer treatment and research
#113
of 164 outputs
Outputs of similar age
#150,377
of 210,284 outputs
Outputs of similar age from Cancer treatment and research
#15
of 17 outputs
Altmetric has tracked 22,725,280 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 164 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
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