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Pharmacology of Potassium Channels

Overview of attention for book
Pharmacology of Potassium Channels
Springer International Publishing
Attention for Chapter: Therapeutic Antibodies Targeting Potassium Ion Channels.
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1 tweeter

Citations

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Chapter title
Therapeutic Antibodies Targeting Potassium Ion Channels.
Book title
Pharmacology of Potassium Channels
Published in
Handbook of experimental pharmacology, May 2021
DOI 10.1007/164_2021_464
Pubmed ID
Book ISBNs
978-3-03-084051-8, 978-3-03-084052-5
Authors

Bednenko, Janna, Colussi, Paul, Hussain, Sunyia, Zhang, Yihui, Clark, Theodore

Abstract

Monoclonal antibodies combine specificity and high affinity binding with excellent pharmacokinetic properties and are rapidly being developed for a wide range of drug targets including clinically important potassium ion channels. Nonetheless, while therapeutic antibodies come with great promise, K+ channels represent particularly difficult targets for biologics development for a variety of reasons that include their dynamic structures and relatively small extracellular loops, their high degree of sequence conservation (leading to immune tolerance), and their generally low-level expression in vivo. The process is made all the more difficult when large numbers of antibody candidates must be screened for a given target, or when lead candidates fail to cross-react with orthologous channels in animal disease models due to their highly selective binding properties. While the number of antibodies targeting potassium channels in preclinical or clinical development is still modest, significant advances in the areas of protein expression and antibody screening are converging to open the field to an avalanche of new drugs. Here, the opportunities and constraints associated with the discovery of antibodies against K+ channels are discussed, with an emphasis on novel technologies that are opening the field to exciting new possibilities for biologics development.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer > Senior Lecturer 1 17%
Unknown 5 83%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 17%
Unknown 5 83%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2021.
All research outputs
#18,759,392
of 21,108,726 outputs
Outputs from Handbook of experimental pharmacology
#528
of 619 outputs
Outputs of similar age
#280,955
of 341,864 outputs
Outputs of similar age from Handbook of experimental pharmacology
#6
of 6 outputs
Altmetric has tracked 21,108,726 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 619 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,864 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.