Report for: Oxytocin

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Chapter title	Use of Cocultures to Measure the Blood-Brain Barrier Permeability of Oxytocin.
Book title	Oxytocin
Published in	Methods in molecular biology, January 2022
DOI	10.1007/978-1-0716-1759-5_15
Pubmed ID	34550579
Book ISBNs	978-1-07-161758-8, 978-1-07-161759-5
Authors	Yamamoto, Yasuhiko, Harashima, Ai, Munesue, Sei-Ichi, Higashida, Haruhiro, Munesue, Sei-ichi
Abstract	Primary monkey brain capillary endothelial cell cultures, with rat pericytes and astrocytes, provide an assay system for predicting the ability of oxytocin (OT) to cross the blood-brain barrier (BBB), using a commercially available in vitro BBB kit. The integrity of the in vitro "BBB," which has a high transendothelial electrical resistance (TEER), can be established approximately 4 days after preparations for experiments. Dominant endothelial transport of OT is from the upper (luminal blood side) to lower (abluminal brain side) chambers, dose-dependently. OT is transported by the receptor for advanced glycation end-products (RAGE) in endothelial cells, which is evidenced using the RAGE knockdown system with short hairpin RNA (shRNA) treatment. This in vitro assay system is useful for further assessment of OT transport across the BBB.

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Geographical breakdown

Country	Count	As %
Australia	1	33%
Unknown	2	67%

Demographic breakdown

Type	Count	As %
Scientists	2	67%
Members of the public	1	33%

Mendeley readers

The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	1	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Bachelor	1	100%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	1	100%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2021.

All research outputs

#15,139,694

of 23,283,373 outputs

Outputs from Methods in molecular biology

#4,822

of 13,326 outputs

Outputs of similar age

#264,627

of 507,564 outputs

Outputs of similar age from Methods in molecular biology

#185

of 596 outputs

Altmetric has tracked 23,283,373 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.

So far Altmetric has tracked 13,326 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 59% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 507,564 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.

We're also able to compare this research output to 596 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.

Oxytocin

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Attention Score in Context