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The Role of Glycosylation in Health and Disease

Overview of attention for book
Cover of 'The Role of Glycosylation in Health and Disease'

Table of Contents

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    Book Overview
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    Chapter 1 N -Glycosylation
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    Chapter 11 The Role of Glycosylation in Infectious Diseases
  4. Altmetric Badge
    Chapter 13 The Role of Glycosylation in Inflammatory Diseases.
Attention for Chapter: Glycosylation and Aging.
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Chapter title
Glycosylation and Aging.
Book title
The Role of Glycosylation in Health and Disease
Published in
Advances in experimental medicine and biology, September 2021
DOI 10.1007/978-3-030-70115-4_17
Pubmed ID
34495544
Book ISBNs
978-3-03-070114-7, 978-3-03-070115-4
Authors

Cindrić, Ana, Krištić, Jasminka, Martinić Kavur, Marina, Pezer, Marija

Abstract

Human lifespan has increased significantly in the last 200 years, emphasizing our need to age healthily. Insights into molecular mechanisms of aging might allow us to slow down its rate or even revert it. Similar to aging, glycosylation is regulated by an intricate interplay of genetic and environmental factors. The dynamics of glycopattern variation during aging has been mostly explored for plasma/serum and immunoglobulin G (IgG) N-glycome, as we describe thoroughly in this chapter. In addition, we discuss the potential functional role of agalactosylated IgG glycans in aging, through modulation of inflammation level, as proposed by the concept of inflammaging. We also comment on the potential to use the plasma/serum and IgG N-glycome as a biomarker of healthy aging and on the interventions that modulate the IgG glycopattern. Finally, we discuss the current knowledge about animal models for human plasma/serum and IgG glycosylation and mention other, less explored, instances of glycopattern changes during organismal aging and cellular senescence.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 1 11%
Student > Ph. D. Student 1 11%
Researcher 1 11%
Unknown 6 67%
Readers by discipline Count As %
Unspecified 1 11%
Agricultural and Biological Sciences 1 11%
Medicine and Dentistry 1 11%
Unknown 6 67%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2021.
All research outputs
#20,710,927
of 23,310,485 outputs
Outputs from Advances in experimental medicine and biology
#4,018
of 4,990 outputs
Outputs of similar age
#356,505
of 430,099 outputs
Outputs of similar age from Advances in experimental medicine and biology
#89
of 116 outputs
Altmetric has tracked 23,310,485 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,990 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 430,099 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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