Chapter title |
Glycosaminoglycans in Neurodegenerative Diseases
|
---|---|
Book title |
The Role of Glycosylation in Health and Disease
|
Published in |
Advances in experimental medicine and biology, September 2021
|
DOI | 10.1007/978-3-030-70115-4_9 |
Pubmed ID | |
Book ISBNs |
978-3-03-070114-7, 978-3-03-070115-4
|
Authors |
Jin, Weihua, Zhang, Fuming, Linhardt, Robert J., Linhardt, Robert J, Weihua Jin, Fuming Zhang, Robert J. Linhardt |
Abstract |
Glycosaminoglycans (GAGs) are linear polysaccharides that consist of alternating disaccharides sequences of uronic acids and/or galactose hexamino sugars most of which are sulfated. GAGs are ubiquitously expressed on the cell surface, in the intracellular milieu and in the extracellular matrix of all animal cells. Thus, GAGs exhibit many essential roles in a variety of physiological and pathological processes. The targets of GAGs are GAG-binding proteins and related proteins that are of significant interest to both the academic community and in the pharmaceutical industry. In this review, the structures of GAGs, their binding proteins, and analogs are presented that further the development of GAGs and their analogs for the treatment of neurodegenerative diseases agents. |
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United Kingdom | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
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Scientists | 2 | 29% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
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Student > Doctoral Student | 2 | 14% |
Student > Ph. D. Student | 1 | 7% |
Unspecified | 1 | 7% |
Student > Master | 1 | 7% |
Other | 0 | 0% |
Unknown | 7 | 50% |
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Biochemistry, Genetics and Molecular Biology | 2 | 14% |
Unspecified | 1 | 7% |
Chemistry | 1 | 7% |
Unknown | 7 | 50% |