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Antibiotic Resistance Protocols

Overview of attention for book
Cover of 'Antibiotic Resistance Protocols'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 The RM Test for Determining Methicillin-Resistant Staphylococcus aureus Lineages
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    Chapter 2 Unravelling the Ecology of Antibiotic Resistant Bacteria in the Nasopharynx
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    Chapter 3 Methods to Determine Antibiotic Resistance Gene Silencing
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    Chapter 4 Studying gene induction of glycopeptide resistance using gene swapping.
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    Chapter 5 Real-Time PCR Methods to Study Expression of Genes Related to Hypermutability
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    Chapter 6 Use of DNA Arrays to Study Transcriptional Responses to Antimycobacterial Compounds
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    Chapter 7 Assays of Sensitivity of Antibiotic-Resistant Bacteria to Hydrogen Peroxide and Measurement of Catalase Activity
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    Chapter 8 Measurements of Heme Levels and Respiration Rate in Salmonella enterica Serovar Typhimurium
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    Chapter 9 Methods to Determine Fitness in Bacteria
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    Chapter 10 Application of Continuous Culture for Measuring the Effect of Environmental Stress on Mutation Frequency in Mycobacterium tuberculosis
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    Chapter 11 Identification of Efflux-Mediated Multi-drug Resistance in Bacterial Clinical Isolates by Two Simple Methods
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    Chapter 12 Evaluation of Efflux Activity of Bacteria by a Semi-automated Fluorometric System
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    Chapter 13 Measuring the Activity of Active Efflux in Gram-Negative Bacteria
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    Chapter 14 Rapid Characterization of β-Lactamases by Multiplex PCR
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    Chapter 15 Rapid Methods for Testing Inhibitors of Mycobacterial Growth
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    Chapter 16 Use of Biofilm Model Systems to Study Antimicrobial Susceptibility
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    Chapter 17 Rapid Analysis of Resistant Mutant Genotypes Using Pyrosequencing ®
Attention for Chapter 10: Application of Continuous Culture for Measuring the Effect of Environmental Stress on Mutation Frequency in Mycobacterium tuberculosis
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Chapter title
Application of Continuous Culture for Measuring the Effect of Environmental Stress on Mutation Frequency in Mycobacterium tuberculosis
Chapter number 10
Book title
Antibiotic Resistance Protocols
Published in
Methods in molecular biology, January 2010
DOI 10.1007/978-1-60327-279-7_10
Pubmed ID
20401591
Book ISBNs
978-1-60327-278-0, 978-1-60327-279-7
Authors

Jon Allnutt, Joanna Bacon, Kim A. Hatch

Abstract

The ability of all pathogens to survive within the host is key to their success in establishing disease. Environmental conditions that affect the growth of a pathogen in the host include nutrient status, environmental pH, oxygen availability, and host defences. Studying the response of Mycobacterium tuberculosis (M. tuberculosis) exposed to these relevant host conditions in vitro will further increase our understanding of how these environments have an impact on the molecular mechanisms M. tuberculosis adopts to combat the effects of external influences such as antimycobacterials. The methods presented here are used to investigate the effect of environmental factors on the development of drug-resistant M. tuberculosis. Cultures grown under controlled conditions in continuous culture are sampled and the frequency with which resistant mutants develop are determined. These studies provide data that aid our understanding of the complex interaction between the host environment and invading bacterium that allow resistant strains to develop and continue to cause disease.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 50%
Student > Doctoral Student 1 17%
Lecturer > Senior Lecturer 1 17%
Student > Master 1 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 67%
Engineering 1 17%
Unknown 1 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2014.
All research outputs
#14,156,397
of 22,687,320 outputs
Outputs from Methods in molecular biology
#4,152
of 13,045 outputs
Outputs of similar age
#131,565
of 163,569 outputs
Outputs of similar age from Methods in molecular biology
#83
of 120 outputs
Altmetric has tracked 22,687,320 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,045 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,569 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.

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