| Chapter title |
Epigenetic changes in inflammatory and autoimmune diseases.
|
|---|---|
| Chapter number | 20 |
| Book title |
Epigenetics: Development and Disease
|
| Published in |
Sub cellular biochemistry, June 2012
|
| DOI | 10.1007/978-94-007-4525-4_20 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-074524-7, 978-9-40-074525-4
|
| Authors |
Nielsen HM, Tost J, Helene Myrtue Nielsen, Jörg Tost Ph.D., Jörg Tost |
| Editors |
Tapas K. Kundu |
| Abstract |
In higher eukaryotic organisms epigenetic modifications are crucial for proper chromatin folding and thereby proper regulation of gene expression. In the last years the involvement of aberrant epigenetic modifications in inflammatory and autoimmune diseases has been recognized and attracted significant interest. However, the epigenetic mechanisms underlying the different disease phenotypes are still poorly understood. As autoimmune and inflammatory diseases are at least partly T cell mediated, we will provide in this chapter an introduction to the epigenetics of T cell differentiation followed by a summary of the current knowledge on aberrant epigenetic modifications that dysfunctional T cells display in various diseases such as type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, and asthma. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| United Kingdom | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Brazil | 1 | 4% |
| Unknown | 21 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 22% |
| Student > Postgraduate | 4 | 17% |
| Student > Ph. D. Student | 3 | 13% |
| Student > Master | 3 | 13% |
| Professor | 2 | 9% |
| Other | 4 | 17% |
| Unknown | 2 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 30% |
| Biochemistry, Genetics and Molecular Biology | 6 | 26% |
| Agricultural and Biological Sciences | 4 | 17% |
| Immunology and Microbiology | 2 | 9% |
| Nursing and Health Professions | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 2 | 9% |