Chapter title |
Epigenetic regulation of cancer stem cell gene expression.
|
---|---|
Chapter number | 18 |
Book title |
Epigenetics: Development and Disease
|
Published in |
Sub cellular biochemistry, June 2012
|
DOI | 10.1007/978-94-007-4525-4_18 |
Pubmed ID | |
Book ISBNs |
978-9-40-074524-7, 978-9-40-074525-4
|
Authors |
Bapat SA, Sharmila A. Bapat |
Editors |
Tapas K. Kundu |
Abstract |
The concept of cancer as a stem cell disease has slowly gained ground over the last decade. A 'stem-like' state essentially necessitates that some cells in the developing tumor express the properties of remaining quiescent, self-renewing and regenerating tumors through establishment of aberrant cellular hierarchies. Alternatively, such capacities may also be reacquired through a de-differentiation process. The abnormal cellular differentiation patterns involved during either process during carcinogenesis are likely to be driven through a combination of genetic events and epigenetic regulation. The role(s) of the latter is increasingly being appreciated in acquiring the requisite genomic specificity and flexibility required for phenotypic plasticity, specifically in a context wherein genome sequences are not altered for differentiation to ensue. In this chapter, the recent advances in elucidating epigenetic mechanisms that govern the self-renewal, differentiation and regenerative potentials of cancer stem cells will be presented. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 11% |
Unknown | 8 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 33% |
Student > Ph. D. Student | 2 | 22% |
Student > Master | 1 | 11% |
Unknown | 3 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 33% |
Medicine and Dentistry | 2 | 22% |
Agricultural and Biological Sciences | 1 | 11% |
Unknown | 3 | 33% |