| Chapter title |
DNA methylation and cancer.
|
|---|---|
| Chapter number | 26 |
| Book title |
Epigenetics: Development and Disease
|
| Published in |
Sub cellular biochemistry, June 2012
|
| DOI | 10.1007/978-94-007-4525-4_26 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-074524-7, 978-9-40-074525-4
|
| Authors |
Gokul G, Khosla S, Gopinathan Gokul, Sanjeev Khosla |
| Editors |
Tapas K. Kundu |
| Abstract |
Cancer has been considered a genetic disease with a wide array of well-characterized gene mutations and chromosomal abnormalities. Of late, aberrant epigenetic modifications have been elucidated in cancer, and together with genetic alterations, they have been helpful in understanding the complex traits observed in neoplasia. "Cancer Epigenetics" therefore has contributed substantially towards understanding the complexity and diversity of various cancers. However, the positioning of epigenetic events during cancer progression is still not clear, though there are some reports implicating aberrant epigenetic modifications in very early stages of cancer. Amongst the most studied aberrant epigenetic modifications are the DNA methylation differences at the promoter regions of genes affecting their expression. Hypomethylation mediated increased expression of oncogenes and hypermethylation mediated silencing of tumor suppressor genes are well known examples. This chapter also explores the correlation of DNA methylation and demethylation enzymes with cancer. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 2% |
| Germany | 4 | <1% |
| United Kingdom | 3 | <1% |
| Belgium | 2 | <1% |
| Canada | 2 | <1% |
| South Africa | 1 | <1% |
| India | 1 | <1% |
| Japan | 1 | <1% |
| Brazil | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 435 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 104 | 23% |
| Researcher | 76 | 17% |
| Student > Master | 54 | 12% |
| Student > Bachelor | 39 | 9% |
| Professor > Associate Professor | 31 | 7% |
| Other | 78 | 17% |
| Unknown | 76 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 133 | 29% |
| Biochemistry, Genetics and Molecular Biology | 101 | 22% |
| Medicine and Dentistry | 71 | 16% |
| Chemistry | 14 | 3% |
| Computer Science | 10 | 2% |
| Other | 46 | 10% |
| Unknown | 83 | 18% |