Chapter title |
Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View.
|
---|---|
Chapter number | 15 |
Book title |
Epigenetics: Development and Disease
|
Published in |
Sub cellular biochemistry, June 2012
|
DOI | 10.1007/978-94-007-4525-4_15 |
Pubmed ID | |
Book ISBNs |
978-9-40-074524-7, 978-9-40-074525-4
|
Authors |
Dhanasekaran K, Kumari S, Kanduri C, Karthigeyan Dhanasekaran, Sujata Kumari, Chandrasekhar Kanduri |
Editors |
Tapas K. Kundu |
Abstract |
The Genome of a eukaryotic cell harbors genetic material in the form of DNA which carries the hereditary information encoded in their bases. Nucleotide bases of DNA are transcribed into complimentary RNA bases which are further translated into protein, performing defined set of functions. The central dogma of life ensures sequential flow of genetic information among these biopolymers. Noncoding RNAs (ncRNAs) serve as exceptions for this principle as they do not code for any protein. Nevertheless, a major portion of the human transcriptome comprises noncoding RNAs. These RNAs vary in size, as well as they vary in the spatio-temporal distribution. These ncRnAs are functional and are shown to be involved in diverse cellular activities. Precise location and expression of ncRNA is essential for the cellular homeostasis. Failures of these events ultimately results in numerous disease conditions including cancer. The present review lists out the various classes of ncRNAs with a special emphasis on their role in chromatin organization and transcription regulation. |
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