| Chapter title |
Effects of Antioxidant Supplements (BioPQQ™) on Cerebral Blood Flow and Oxygen Metabolism in the Prefrontal Cortex.
|
|---|---|
| Chapter number | 29 |
| Book title |
Oxygen Transport to Tissue XXXVIII
|
| Published in |
Advances in experimental medicine and biology, January 2016
|
| DOI | 10.1007/978-3-319-38810-6_29 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-938808-3, 978-3-31-938810-6
|
| Authors |
Masahiko Nakano, Yuta Murayama, Lizhen Hu, Kazuto Ikemoto, Tatsuo Uetake, Kaoru Sakatani, Nakano, Masahiko, Murayama, Yuta, Hu, Lizhen, Ikemoto, Kazuto, Uetake, Tatsuo, Sakatani, Kaoru |
| Editors |
Qingming Luo, Lin Z. Li, David K. Harrison, Hua Shi, Duane F. Bruley |
| Abstract |
Pyrroloquinoline quinone (PQQ) is a quinone compound originally identified in methanol-utilizing bacteria and is a cofactor for redox enzymes. At the Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) 2014, we reported that PQQ disodium salt (BioPQQ™) improved cognitive function in humans, as assessed by the Stroop test. However, the physiological mechanism of PQQ remains unclear. In the present study, we measured regional cerebral blood flow (rCBF) and oxygen metabolism in prefrontal cortex (PFC), before and after administration of PQQ, using time-resolved near-infrared spectroscopy (tNIRS). A total of 20 healthy subjects between 50 and 70 years of age were administered BioPQQ™ (20 mg) or placebo orally once daily for 12 weeks. Hemoglobin (Hb) concentration and absolute tissue oxygen saturation (SO2) in the bilateral PFC were evaluated under resting conditions using tNIRS. We found that baseline concentrations of hemoglobin and total hemoglobin in the right PFC significantly increased after administration of PQQ (p < 0.05). In addition, decreases in SO2 level in the PFC were more pronounced in the PQQ group than in the placebo group (p < 0.05). These results suggest that PQQ causes increased activity in the right PFC associated with increases in rCBF and oxygen metabolism, resulting in enhanced cognitive function. |
X Demographics
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| Country | Count | As % |
|---|---|---|
| United States | 22 | 34% |
| Australia | 3 | 5% |
| Canada | 3 | 5% |
| United Kingdom | 2 | 3% |
| France | 1 | 2% |
| New Zealand | 1 | 2% |
| Brazil | 1 | 2% |
| Japan | 1 | 2% |
| Thailand | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 30 | 46% |
Demographic breakdown
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|---|---|---|
| Members of the public | 54 | 83% |
| Practitioners (doctors, other healthcare professionals) | 7 | 11% |
| Scientists | 4 | 6% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 21% |
| Researcher | 8 | 19% |
| Student > Bachelor | 5 | 12% |
| Student > Doctoral Student | 3 | 7% |
| Student > Ph. D. Student | 3 | 7% |
| Other | 6 | 14% |
| Unknown | 8 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 21% |
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| Sports and Recreations | 4 | 10% |
| Chemistry | 3 | 7% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Other | 9 | 21% |
| Unknown | 10 | 24% |