Chapter title |
Skeletal Muscle Regeneration in the Mouse
|
---|---|
Chapter number | 19 |
Book title |
Skeletal Muscle Regeneration in the Mouse
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3810-0_19 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3808-7, 978-1-4939-3810-0
|
Authors |
Sperringer, Justin E, Grange, Robert W, Justin E. Sperringer, Robert W. Grange |
Editors |
Michael Kyba |
Abstract |
In vitro muscle contractile function assays are important to characterize the differences between different muscle types (e.g., slow vs. fast), between a diseased and non-diseased muscle, or importantly, to demonstrate the efficacy of a muscle treatment such as a drug, an overexpressed transgene, or knockout of a specific gene. Fundamental contractile properties can be assessed by twitch, tetanic, force-frequency, force-velocity, and fatigue assays. Many of these assays are conducted with the muscle at a constant length, e.g., an isometric contraction. However, to better represent the dynamic purpose of muscles in vivo (e.g., to move limbs), dynamic assays such as the force-velocity (concentric contractions) or stretch-injury (eccentric contractions) should also be obtained. Characterizing skeletal muscle function in vitro is a powerful approach to demonstrate efficacy of a treatment to rescue diseased muscle and to assess functional regeneration. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 27% |
Student > Ph. D. Student | 6 | 23% |
Student > Bachelor | 3 | 12% |
Lecturer | 1 | 4% |
Professor | 1 | 4% |
Other | 3 | 12% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 31% |
Agricultural and Biological Sciences | 4 | 15% |
Medicine and Dentistry | 3 | 12% |
Sports and Recreations | 3 | 12% |
Immunology and Microbiology | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 19% |